Juste dose
Loden
, 1995Clinical test on 10 volunteers aged 25 to 53.
Protocol:
0.5 and 2% salicylic acid applied on the arm, then stripping tests (at 6h after the application) to assess the keratolytic effect. The stripping test is realised with transparent adhesive tape, then the transmission of light through the tape is measured with a digital light measuring instrument. The transmission values are converted into absorbance.
Results:
Exposing the arm to 2% salicylic acid for 6 hours significantly increased the amount of tissue found on the adhesive tape (p<0.05) (increase of 37% in absorbance value). No significant increase was observed with 0.5% salicylic acid.
Zander
, 1992Clinical study on 180 volunteers with acne, aged 12 to 22 years.
Protocol:
application during 12 weeks on face. Evaluation by clinical counting of inflammatory lesions, opens comedones, closes comedones, and total lesions.
Results:
At each evaluation (weeks 4,6,8,10,12), 2% salicylic acid was found to be superior to the vehicle for the reduction of inflammatory lesions and open comedones. Excellent or good responses in inflammatory lesion reduction were achieved in 86% of patients treated with 2% salicylic acid, vs 11% with the vehicle control. At final evaluation (12weeks) : 2% salicylic acid produces a greater reduction form baseline in all evaluated parameters: +184% in reduction of total lesions counting, +187% in reduction of inflammatory lesions, + 154% in reduction of open comedones, and + 149% in reduction of closes comedones.